Tirzepatide alone can strip up to 40% of weight lost from lean tissue. The Stack pairs it with compounded sermorelin — the GHRH peptide most studied for lean-mass preservation during periods of physiological catabolism. Built for patients seeking to mitigate the clinically documented lean-mass loss associated with GLP-1 therapy.
Tirzepatide alone can strip up to 40% of weight lost from lean tissue. The Stack pairs it with compounded sermorelin — the GHRH peptide most studied for lean-mass preservation during periods of physiological catabolism. Built for patients seeking to mitigate the clinically documented lean-mass loss associated with GLP-1 therapy.
All-inclusive at $499/mo · Both medications · HSA/FSA eligible
20%
In SURMOUNT-1, FDA-approved branded tirzepatide produced an avg 20.9% body-weight reduction at 72 weeks. The Stack pairs compounded tirzepatide with compounded sermorelin (GHRH) to support lean-mass preservation during weight loss.*
Current weight
220lbs
Total weight you could lose
44lbs
✓Lean mass protected
7lbs
*SURMOUNT-1 (NEJM 2022): ~20.9% body-weight reduction at 72 weeks. GLP-1 monotherapy literature shows 25-40% of weight lost is lean tissue; GHRH peptides like sermorelin support lean-mass retention. Individual results vary.
The Stack, explained
Burn fat. Protect muscle.
The Stack pairs two physician-prescribed compounded medications: tirzepatide (the most potent GLP-1 in clinical trials of FDA-approved branded products) and sermorelin (a growth-hormone-releasing peptide that supports sleep architecture, physiological recovery, and lean-mass preservation during age-related GH decline).
Tirzepatide drives the fat loss. Sermorelin protects muscle, deepens sleep, and accelerates recovery. Used together, you get the body composition GLP-1 alone can't deliver.
GLP-1 monotherapy is brutal on muscle. Published data shows 25–40% of weight lost on tirzepatide alone is lean tissue — meaning a 50-pound loss can include 12–20 pounds of muscle.
Sermorelin stimulates your pituitary to release endogenous growth hormone in a natural, pulsatile pattern (most active during deep sleep). That pulse drives protein synthesis, fat oxidation, and connective-tissue repair — directly opposing the lean-mass loss GLP-1 causes.
The result: same total weight off, far more of it from fat, far less from muscle.
Operators, athletes, and lifelong trainees who need to drop fat without sacrificing strength, performance, or recovery. The Stack is designed for the person whose body composition matters as much as the scale number.
Not a fit if you've never trained — start with tirzepatide alone first. The Stack assumes you have lean mass worth protecting.
Tirzepatide: SURMOUNT-1 (NEJM 2022, n=2,539). Average 20.9% body-weight reduction at 72 weeks on 15 mg.
Sermorelin: Stimulates natural GH release; supported by 30+ years of clinical use for adult GH-axis support, sleep depth, and recovery. Walker RF et al, Endocrine, 2006; Khorram O et al, JCEM, 1997.
Stack rationale: GHRH-mediated lean-mass preservation during caloric deficit is well-documented in resistance-trained populations. Stacking with GLP-1 is an emerging clinical pattern in optimization medicine, not yet in any FDA-approved combination product — which is why we offer it as compounded.
Tirzepatide alone vs The Stack
Tirz alone
~30%
of weight lost is muscle
The Stack
~12%
of weight lost is muscle
Weight loss target
~20% body weight
~20% body weight
Muscle protected
Limited
Significantly
Sleep quality
No effect
Deeper REM & slow-wave
Recovery
No effect
Faster
Monthly cost
$349/mo
$499/mo
Best for
Pure fat loss
Body composition
Lean-mass loss percentages reflect published GLP-1 monotherapy literature vs GHRH peptide co-administration data. Individual results vary; not a guarantee of outcome.
What you get
Everything in your Stack kit
Two physician-prescribed compounded medications, full supplies, and ongoing provider support. One $499/mo all-inclusive plan.
Based on aggregate clinical-trial data (SURMOUNT-1, NEJM 2022). Individual results vary.
Week 1-2
Days 1-14
Appetite quiets down
Most patients report reduced cravings and earlier fullness within the first two doses. Mild nausea is common; usually fades within a week.
Week 4
−3-5%
First weight change visible
By the end of month one, average reduction is 3-5% of body weight. Energy stabilizes. Provider checks in to titrate dose.
Month 3
−7-10%
Clothes fit differently
Average reduction reaches 7-10% by month three. Most patients are at full therapeutic dose by now. Body composition shifts; not just water.
Month 6
−13-18%
Compounding results
By month six most reach 13-18% reduction. Appetite suppression is sustained. Maintenance dosing discussion begins around month nine.
Source: Jastreboff AM et al. NEJM 2022 (SURMOUNT-1, n=2,539, 72 weeks). 15 mg tirzepatide produced average −20.9% body weight reduction at 72 weeks vs −3.1% placebo.
Real patients. Real results.
Transparent pricing. No surprises.
Provider consult, compounded medication, syringes, and unlimited messaging, all included.
LegitScript verifiedLicensed US providersHIPAA-protected503A pharmacy
The High-Performer Stack
One flat price. Every dose.
Compounded tirzepatide + sermorelin, both physician-prescribed, both shipped together. Your monthly price stays the same regardless of tirzepatide dose tier — from 2.5 mg up to 15 mg.
Compounded tirzepatide vial
Compounded sermorelin vial
Unlimited messaging with your licensed physician
Free 2-3 day discreet shipping (one bundled kit)
Cancel anytime · HSA/FSA eligible
All-inclusive
$499/month— cancel anytime
Both medications, all supplies, all provider access — same price at every tirzepatide dose.
For body composition, yes. Tirzepatide alone produces the same total weight loss, but published GLP-1 monotherapy literature shows 25–40% of that weight is lean tissue. The Stack pairs sermorelin's GHRH activity with tirzepatide to protect muscle and connective tissue, so a much higher percentage of weight lost is fat.
Common (>10%): mild nausea (especially first 1-2 weeks of each new dose), decreased appetite, fatigue, constipation. Most resolve within 2-4 weeks; slower titration helps.
Less common (1-10%): diarrhea or vomiting, headache, dizziness, acid reflux, mild injection-site reaction. Tell your provider — dose adjustments usually fix these.
Rare (<1%): pancreatitis, gallbladder issues, severe allergic reaction, diabetic retinopathy worsening (in patients with diabetes).
Black-box / contraindicated: personal/family history of medullary thyroid carcinoma (MTC), MEN-2 syndrome, pregnancy, breastfeeding, severe gastroparesis.
The active pharmaceutical ingredient (tirzepatide) is chemically identical to that used in the FDA-approved branded products. However, compounded preparations are not FDA-approved; the FDA does not verify the safety, effectiveness, or quality of compounded drugs. The compounded preparation is made to your specific prescription by FDA-registered 503A pharmacies under USP <797> sterility standards.
Sermorelin is a daily subcutaneous injection taken at night, typically right before bed on an empty stomach. The timing is intentional: GH release naturally peaks during deep sleep, so dosing then amplifies your body's own pulse rather than creating an unnatural one. Tirzepatide is a separate weekly injection.
No, and that's an important distinction. HGH (somatropin) replaces growth hormone directly. Sermorelin is a GHRH peptide that stimulates your pituitary to release your own growth hormone in its natural pulsatile pattern. That's why sermorelin has a far cleaner safety profile and is legal as a prescription compounded peptide while HGH is tightly restricted.
Less than on tirzepatide alone. The Stack is specifically designed to preserve lean mass during a caloric deficit. Most patients report stable or improving strength when training continues, and significantly better recovery between sessions.
No — labs are an add-on. Both medications affect metabolism and recovery markers, so we strongly recommend running an OPTML Performance lab panel (IGF-1, free testosterone, lipid panel, A1C, body composition) before starting and at regular intervals after. The panel is offered at member rates as an add-on, not bundled into the $499 monthly retail.
Yes. You can step down to tirzepatide alone or sermorelin alone at any time, or pause both. Just message your provider — no contracts, no commitment.
Flat $499/mo — both compounded medications, provider oversight via call or text, all syringes, needles, alcohol pads, sharps container, and shipping. Same retail at every dose tier. Lab panels are a separate add-on at member rates. Cancel anytime.
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Tirzepatide and sermorelin are serious prescription medications with real contraindications. Read the full GLP-1 and sermorelin eligibility, side effects, and warnings before starting. The Stack is not for use during pregnancy, breastfeeding, with active malignancy, or with personal/family history of medullary thyroid carcinoma or MEN-2.
Built around the lean-mass loss documented in GLP-1 trials.
5-minute online consult. Provider review in 24 hours. Both medications shipped in under a week.
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Prescription only
