The Protocol pairs compounded tirzepatide for medically-supervised weight loss with compounded sermorelin, a GHRH peptide that supports deeper sleep and physiological recovery. One physician-led plan for patients who want GH-axis support for sleep and recovery alongside their weight-loss protocol.
✓GLP-1 weight loss + GHRH sleep & recovery support
Prescription onlyPrescribed by U.S.-licensed physicians
The Protocol, explained
Lose weight. Sleep and recover.
The Protocol pairs two physician-prescribed compounded medications: tirzepatide (a dual GIP / GLP-1 receptor agonist used in physician-supervised weight-management protocols) and sermorelin (a growth-hormone-releasing peptide that supports sleep architecture and physiological recovery during age-related GH decline).
Tirzepatide supports medical weight loss; sermorelin supports the body's natural GH/IGF-1 axis, deeper sleep, and physiological recovery. A physician may pair them for patients who want sleep and recovery support during weight loss. Individual results vary.
Weight loss can be demanding on sleep and recovery. Sermorelin supports the body's own growth-hormone axis, which is most active during deep sleep.
Sermorelin stimulates your pituitary to release endogenous growth hormone in a natural, pulsatile pattern, most active during deep sleep — supporting sleep depth and physiological recovery.
The result is weight-loss support alongside GH-axis support for sleep and recovery. Individual results vary.
Adults pursuing medically-supervised weight loss who also want GH-axis support for sleep and recovery. The Protocol pairs a GLP-1 with GHRH support for a more comprehensive plan.
Your physician will confirm whether it fits you during intake. Individual results vary.
Tirzepatide: a dual GIP and GLP-1 receptor agonist. The literature describes the dual mechanism as having a stronger appetite-modulation profile than GLP-1 alone.
Sermorelin: Stimulates natural GH release; supported by 30+ years of clinical use for adult GH-axis support, sleep depth, and recovery. Walker RF et al, Endocrine, 2006; Khorram O et al, 1997.
Stack rationale: Sermorelin's GH-axis, sleep, and recovery support is documented in adults with age-related GH decline. Pairing it with GLP-1 weight loss is an emerging clinical pattern, not yet in any FDA-approved combination product — which is why we offer it as compounded.
Tirzepatide alone vs The Protocol
Tirz alone
1
medication
The Protocol
2
medications
Weight loss target
~20% body weight
~20% body weight
GH-axis support
No
Yes
Sleep quality
No effect
Deeper REM & slow-wave
Recovery
No effect
Faster
Monthly cost
$349/mo
$498/mo
Best for
Weight loss
Weight loss + recovery
Comparison reflects a single-medication vs two-medication protocol. Compounded preparations are not FDA-approved. Individual results vary; not a guarantee of outcome.
What you get
Everything in your Stack kit
Two physician-prescribed compounded medications, full supplies, and ongoing provider support. One $498/mo all-inclusive plan.
Provider consult, compounded medication, syringes, and ongoing clinical support, all included.
Physician-directed care
A U.S.-licensed physician personally reviews every order before anything is prescribed.
U.S.-licensed physicians
Reviews every order
LegitScript Certified
503A pharmacy · USP <797>
The High-Performer Protocol
One flat price. Every dose.
Compounded tirzepatide + sermorelin, both physician-prescribed, both shipped together. Your monthly price stays the same regardless of tirzepatide dose tier — from 2.5 mg up to 15 mg.
Compounded tirzepatide vial
Compounded sermorelin vial
Ongoing clinical support
Free 2-3 day discreet shipping (one bundled kit)
Cancel anytime · HSA/FSA eligible
All-inclusive
$498/month— cancel anytime
Both medications, all supplies, all provider access — same price at every tirzepatide dose.
Your physician titrates both medications based on your response. Sleep quality is among the effects discussed in the clinical literature; individual results vary.
Your monthly price includes everything.
Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.
Sermorelin supports the body's natural GH/IGF-1 axis, sleep depth, and recovery, which is part of why a physician may pair the two during medical weight loss. Whether this approach fits you is determined by your physician. Compounded preparations are not FDA-approved or evaluated by the FDA for safety, effectiveness, or quality. Individual results vary.
Common (>10%): mild nausea (especially first 1-2 weeks of each new dose), decreased appetite, fatigue, constipation. Most resolve within 2-4 weeks; slower titration helps.
Less common (1-10%): diarrhea or vomiting, headache, dizziness, acid reflux, mild injection-site reaction. Tell your provider — dose adjustments usually fix these.
Rare (<1%): pancreatitis, gallbladder issues, severe allergic reaction, diabetic retinopathy worsening (in patients with diabetes).
Black-box / contraindicated: personal/family history of medullary thyroid carcinoma (MTC), MEN-2 syndrome, pregnancy, breastfeeding, severe gastroparesis.
OPTML's compounded tirzepatide is prepared by FDA-registered 503A pharmacies under USP <797> sterility standards, on prescription by a U.S. licensed physician. Compounded medications are not FDA-approved.
Sermorelin is a daily subcutaneous injection taken at night, typically right before bed on an empty stomach. The timing is intentional: GH release naturally peaks during deep sleep, so dosing then amplifies your body's own pulse rather than creating an unnatural one. Tirzepatide is a separate weekly injection.
No, and that's an important distinction. HGH (somatropin) replaces growth hormone directly. Sermorelin is a GHRH peptide that stimulates your pituitary to release your own growth hormone in its natural pulsatile pattern. That's why sermorelin has a far cleaner safety profile and is legal as a prescription compounded peptide while HGH is tightly restricted.
Sermorelin supports your body's own growth-hormone axis, which is most active during deep sleep and is involved in sleep quality and physiological recovery. Adequate protein and healthy activity support your results during a weight-loss phase. Individual results vary.
No — labs are an add-on. Both medications affect metabolic and hormone markers, so we strongly recommend running an OPTML lab panel (IGF-1, free testosterone, lipid panel, A1C) before starting and at regular intervals after. The panel is offered at member rates as an add-on, not bundled into the $498 monthly retail.
Yes. You can step down to tirzepatide alone or sermorelin alone at any time, or pause both. Just message your provider — no contracts, no commitment.
Flat $498/mo — both compounded medications, provider oversight via call or text, all syringes, needles, alcohol pads, sharps container, and shipping. Same retail at every dose tier. Lab panels are a separate add-on at member rates. Cancel anytime.
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Tirzepatide and sermorelin are serious prescription medications with real contraindications. Read the full GLP-1 and sermorelin eligibility, side effects, and warnings before starting. The Protocol is not for use during pregnancy, breastfeeding, with active malignancy, or with personal/family history of medullary thyroid carcinoma or MEN-2.
Weight loss, with GH-axis support for sleep and recovery.
5-minute online consult. Provider review in 24 hours. Both medications shipped in under a week.
Weight-loss medication disclaimer. OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.
LegitScript CertifiedHealthcare Merchant
Prescription only
