Two GLP-1 protocols · One online consult

Compounded GLP-1,
prescribed online.

Two GLP-1 molecules. In SURMOUNT-1, FDA-approved branded tirzepatide (Zepbound® 15 mg) produced an average 20.9% body-weight reduction at 72 weeks. In STEP-1, FDA-approved branded semaglutide (Wegovy® 2.4 mg) produced an average 14.9% at 68 weeks. OPTML dispenses both as compounded preparations through licensed 503A pharmacy partners (Strive · Boothwyn · Absolute).

SURMOUNT-1 and STEP-1 studied FDA-approved branded preparations, not compounded preparations. Compounded preparations are not FDA-approved or evaluated by the FDA for safety, effectiveness, or quality. Individual results vary.

All-inclusive pricing — no membership fees
Provider-matched: tirzepatide or semaglutide
503A licensed pharmacies (USP <797>) · Cancel anytime
Only at OPTML
GLP-1 Muscle Loss Protocol included
Resistance-training program built around GLP-1 weight loss — because losing fat without muscle is the goal.

Get started See the comparison →

Compounded medication is not FDA-approved. Sema $249/mo · Tirz $349/mo · HSA/FSA eligible.

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Prescription only 4.9 · 200,000+ patients

Weight Loss · GLP-1

★★★★★4.9 / 200,000+ patients across our provider network

Two GLP-1s. One protocol. Choose the right fit.

Tirzepatide and semaglutide are both prescribed online by U.S. licensed providers, compounded at 503A pharmacies, and shipped to your door monthly. Your provider helps you choose based on your starting weight, goals, and how your body responds.

All-inclusive pricing — no membership fees
503A licensed pharmacies (USP <797>)
U.S.-licensed providers · Cancel anytime
GLP-1 Muscle Loss Protocol included

Start your free assessment See the comparison

Starting at $249/mo · Free provider consult · HSA/FSA eligible

Step 1 of 3 · Choose your GLP-1

Tirzepatide or semaglutide? It depends on your goal.

Both medications are FDA-approved active ingredients prescribed by U.S. licensed providers. Your provider helps you choose based on your starting weight, side-effect tolerance, and clinical goals.

Tirzepatide

20.9% avg in SURMOUNT-1.

Dual GIP/GLP-1 receptor agonist. In the SURMOUNT-1 trial of FDA-approved branded tirzepatide (Zepbound® 15 mg), participants averaged a 20.9% body-weight reduction at 72 weeks. OPTML dispenses the compounded preparation; compounded preparations are not FDA-approved.

Start tirzepatide $349/mo · SURMOUNT-1, 72 weeks

Semaglutide

14.9% avg in STEP-1.

GLP-1 receptor agonist. In the STEP-1 trial of FDA-approved branded semaglutide (Wegovy® 2.4 mg), participants averaged a 14.9% body-weight reduction at 68 weeks. OPTML dispenses the compounded preparation; compounded preparations are not FDA-approved.

Start semaglutide $249/mo · STEP-1, 68 weeks

Tirzepatide · Maximum results

Compounded Tirzepatide

Dual-receptor GLP-1/GIP agonist. In trials of the FDA-approved branded preparations (Zepbound®, Mounjaro®), tirzepatide produced the largest average weight-loss effect of any GLP-1-class molecule studied to date. Compounded preparations are not FDA-approved.

20.9% avg body-weight reduction (SURMOUNT-1, branded tirzepatide 15 mg, 72 weeks)
Dual GIP/GLP-1 mechanism, appetite + glucose
Once-weekly subcutaneous injection
Standard titration: 2.5 → 5 → 7.5 → 10 → 15 mg

$349/mo · provider consult included

Start tirzepatide Learn more

Semaglutide · Proven first-line

Compounded Semaglutide

GLP-1 receptor agonist. The FDA-approved branded preparations (Ozempic® for type 2 diabetes; Wegovy® for chronic weight management, both Novo Nordisk) are the most clinically validated GLP-1 in the U.S. The same molecule can also be prepared as a compounded preparation by a licensed 503A pharmacy. Compounded preparations are not FDA-approved.

14.9% avg body-weight reduction (STEP-1, branded semaglutide 2.4 mg, 68 weeks)
Single GLP-1 receptor mechanism
Once-weekly subcutaneous injection
Standard titration: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg

$249/mo · provider consult included

Start semaglutide Learn more

Not sure which fits? Take the 60-second protocol quiz, your provider routes you based on starting weight, goals, and tolerance.

Step 2 of 3 · Estimate your results

See what's possible at your starting weight.

Toggle between tirzepatide and semaglutide to compare clinical-trial outcomes at your weight.

--%

On average, people on Tirzepatide lose 20% of their body weight in 12 months.*

Current weight

220lbs

Weight you could lose

44lbs

*Clinical trial data is from studies of FDA-approved tirzepatide (Zepbound®) in non-diabetic patients with obesity, paired with healthy lifestyle changes. Compounded preparations are not FDA-approved; the FDA does not verify the safety, effectiveness, or quality of compounded drugs. Individual results vary.

Start your free assessment

Step 3 of 3 · How it works

From consult to first shipment in under a week.

Lab review, physician oversight, and medication shipped to your door, same protocol whether you choose tirzepatide or semaglutide.

Free consult

4-minute intake. A U.S. licensed provider reviews your history, BMI, and goals.

Provider matches your GLP-1

Tirzepatide or semaglutide, your provider recommends based on starting weight, goals, and tolerance.

Prescribed & shipped

Compounded at a 503A pharmacy. Discreet, insulated shipping in 2-3 business days.

Ongoing care

Unlimited messaging. Dose titration adjusted by your provider as you progress.

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Question 1 of 12

What do you want to accomplish with OPTML?

Lose weight
Build muscle & performance
Sleep & recovery
Optimize hormones

Start losing weight in 4 simple steps

Free consult
4-minute intake. A U.S. licensed provider reviews your history, BMI, and goals.
Provider matches your GLP-1 (tirz or sema)
Prescribed & shipped in 2-3 days
Ongoing provider support & titration

Frequently asked questions

In trials of the FDA-approved branded preparations, branded tirzepatide produced more weight loss on average (20.9% in SURMOUNT-1 at 72 weeks) than branded semaglutide (14.9% in STEP-1 at 68 weeks). However, semaglutide has the longer track record, broader real-world data, and a lower price point. Your OPTML provider helps you decide based on your starting weight, side-effect tolerance, and budget. Compounded preparations of either molecule are not FDA-approved.

OPTML's compounded preparations are prepared from the same active pharmaceutical ingredients used in the FDA-approved branded products — semaglutide (Ozempic®, Wegovy®) and tirzepatide (Mounjaro®, Zepbound®). The compounded preparations are made to your specific prescription by FDA-registered 503A pharmacies under USP <797> sterility standards. However, compounded preparations are not FDA-approved; the FDA does not verify the safety, effectiveness, or quality of compounded drugs before they are marketed.

Yes. Many patients start on semaglutide and switch to tirzepatide if they want a stronger response or plateau. Your provider handles the transition and dose recalibration.

Both have similar GI side effect profiles, nausea, constipation, and occasional fatigue, especially during dose escalation. Tirzepatide's dual-receptor mechanism can produce slightly more pronounced GI effects in some patients. Your provider titrates slowly to minimize discomfort.

Compounded semaglutide starts at $249/mo. Compounded tirzepatide starts at $349/mo. Both include the provider consult, medication, supplies, and ongoing messaging. HSA/FSA eligible.

OPTML services all 50 states with licensed telehealth providers. Some states require additional documentation, we'll let you know during intake.

Compounded GLP-1,
prescribed online.

Two GLP-1s. One protocol. Choose the right fit.