What are the side effects?

Most common: nausea, constipation, diarrhea, fatigue, typically mild and temporary. Side effect profile is similar to semaglutide. Your provider starts you at a low dose and titrates up slowly.

Dual GIP/GLP-1 weight-loss molecule

Compounded tirzepatide,
prescribed online.

Tirzepatide activates two metabolic pathways — both GIP and GLP-1 receptors. In the SURMOUNT-1 trial of FDA-approved branded tirzepatide (Zepbound® 15 mg weekly), participants averaged a 20.9% body-weight reduction at 72 weeks. OPTML dispenses tirzepatide as a compounded preparation, prescribed by U.S.-licensed providers and filled by our 503A pharmacy partners.

SURMOUNT-1 studied FDA-approved branded tirzepatide, not compounded preparations. Compounded preparations are not FDA-approved or evaluated by the FDA for safety, effectiveness, or quality. Individual results vary.

All-inclusive pricing — no membership fees
503A licensed pharmacies (USP <797>)
Free 2-3 day discreet shipping · cancel anytime
Only at OPTML
GLP-1 Muscle Loss Protocol included
Resistance-training program built around GLP-1 weight loss — because losing fat without muscle is the goal.

Get started See SURMOUNT-1 trial data →

Compounded medication is not FDA-approved. Starting at $349/mo · HSA/FSA eligible.

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Prescription only 4.9 · 200,000+ patients

Weight Loss · Dual GIP/GLP-1

★★★★★4.9 / 200,000+ patients across our provider network

Tirzepatide — the dual-pathway molecule, prescribed and delivered.

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Tirzepatide is the only weight-loss molecule that activates two metabolic pathways — both GIP and GLP-1 receptors. In the SURMOUNT-1 trial of FDA-approved branded tirzepatide (Zepbound® 15 mg weekly), participants averaged a 20.9% body-weight reduction at 72 weeks. OPTML dispenses tirzepatide as a compounded preparation, prescribed by U.S.-licensed providers and filled by our licensed 503A pharmacy partners (Strive · Boothwyn · Absolute).

All-inclusive pricing — no membership fees
503A licensed pharmacies (USP <797> standards)
U.S.-licensed providers
Cancel anytime, no contract
Discreet 2–3 day shipping

Only at OPTML

GLP-1 Muscle Loss Protocol included

Resistance-training program built around GLP-1 weight loss — because losing fat without muscle is the goal. No other compounded-GLP-1 provider includes this.

Start your free assessment How it works

Starting at $349/mo · Free provider consult · HSA/FSA eligible

SURMOUNT-1 Trial · 72 weeks · Branded tirzepatide

20%

In the SURMOUNT-1 trial of FDA-approved branded tirzepatide, participants averaged a 20.9% body-weight reduction over 72 weeks at the 15 mg weekly dose.*

Current weight

220lbs

Trial average at your weight

44lbs

*SURMOUNT-1 studied FDA-approved branded tirzepatide (Zepbound® 15 mg). Compounded preparations are not FDA-approved or evaluated by FDA. Individual results vary. Educational reference only.

Tirzepatide, explained

The most studied molecule in the GLP-1 class.

Tirzepatide is a once-weekly injectable molecule that activates two metabolic receptors, GIP and GLP-1. In clinical trials of the FDA-approved branded preparations (Mounjaro® for type 2 diabetes; Zepbound® for chronic weight management, both manufactured by Eli Lilly), tirzepatide produced the largest average weight-loss effect of any GLP-1-class molecule studied to date.

The same molecule can also be prepared by licensed 503A compounding pharmacies as a personalized prescription. OPTML’s compounded tirzepatide is prescribed by U.S.-licensed providers and filled by our 503A pharmacy partners (Strive · Boothwyn · Absolute) under USP <797> sterility standards, then shipped to your door monthly. Compounded preparations are not FDA-approved or evaluated by FDA for safety, effectiveness, or quality.

Semaglutide (Ozempic, Wegovy) activates a single receptor: GLP-1. Tirzepatide activates two: GIP and GLP-1. The dual mechanism is why tirzepatide produces stronger weight loss in head-to-head data.

In SURMOUNT-5 (NEJM 2025), FDA-approved branded tirzepatide produced roughly 50% more weight loss than FDA-approved branded semaglutide over 72 weeks at maximum tolerated doses. The trial studied branded preparations, not compounded preparations.

Tirzepatide is for patients prioritizing maximum weight loss, who tolerate stronger appetite suppression, and who want the dual GIP/GLP-1 mechanism. In SURMOUNT-1, FDA-approved branded tirzepatide produced an average 20.9% body-weight reduction at 15 mg weekly over 72 weeks.

Semaglutide is for patients who want a gentler on-ramp, smaller doses, or have responded well to GLP-1-only therapy. In STEP-1, FDA-approved branded semaglutide produced an average 14.9% body-weight reduction at 2.4 mg weekly over 68 weeks.

Your OPTML provider helps you choose based on starting weight, tolerance, and goals.

SURMOUNT-1 (NEJM 2022, n=2,539) was the largest tirzepatide weight-loss trial ever run. At 72 weeks on the 15 mg dose, patients lost an average of 20.9% of body weight, with 91% losing at least 5%, and average waist reduction of 7.4 inches.

Source: Jastreboff AM et al. New England Journal of Medicine. SURMOUNT-1. 2022.

What you get

Everything in your tirzepatide kit

No surprises, no upsells. Each shipment includes everything you need to administer safely at home, plus full clinical support.

Compounded tirzepatide

Sterile, multi-dose vials. Doses titrated 2.5 → 15 mg by your provider.

Sterile syringes & needles

Pre-paired insulin syringes sized for subcutaneous injection.

Alcohol pads + sharps bin

Everything for safe, sanitary self-administration at home.

Provider + care messaging

U.S.-licensed provider review and unlimited messaging access.

Discreet 2-3 day shipping

Insulated, temperature-controlled, plain packaging. Always free.

Customer reviewing her OPTML protocol on her phone

How it works

Start tirzepatide in 5 simple steps.

Online assessment to first shipment in under a week. No in-person visits, no waiting rooms.

Start your free assessment →

Take the free assessment

Answer a few questions about your health, weight history, and goals. Takes about 5 minutes online.

Provider reviews your info

A U.S. licensed provider reviews your assessment and prescribes the right dose, if appropriate. You'll hear back from your provider.

Get your kit shipped

If prescribed, your compounded tirzepatide, syringes, and supplies ship discreetly in 2-3 days. Free 2-3 day shipping always.

Inject once a week

Self-administer at home. Most patients report reduced cravings and steady weight loss within 2-4 weeks.

Get ongoing support

Message your provider anytime. Dose adjustments, refills, and side-effect questions handled in-app. Cancel anytime.

9:41

Question 1 of 12

What do you want to accomplish with OPTML?

Lose weight
Build muscle & performance
Optimize hormones
Improve sleep & recovery

Start losing weight in 5 simple steps

Take the free assessment

Answer a few questions about your health, weight history, and goals — about 5 minutes, all online.
Provider writes an Rx (if appropriate)
Get your kit shipped in 2-3 days
Inject once a week at home
Get ongoing provider support

Start your free assessment →

No commitment. No insurance needed. See full eligibility & contraindications →

What to expect

Your typical 24-week journey on tirzepatide

Based on aggregate clinical-trial data (SURMOUNT-1, NEJM 2022). Individual results vary.

Week 1-2

Days 1-14

Appetite quiets down

Most patients report reduced cravings and earlier fullness within the first two doses. Mild nausea is common; usually fades within a week.

Week 4

−3-5%

First weight change visible

By the end of month one, average reduction is 3-5% of body weight. Energy stabilizes. Provider checks in to titrate dose.

Month 3

−7-10%

Clothes fit differently

Average reduction reaches 7-10% by month three. Most patients are at full therapeutic dose by now. Body composition shifts; not just water.

Month 6

−13-18%

Compounding results

By month six most reach 13-18% reduction. Appetite suppression is sustained. Maintenance dosing discussion begins around month nine.

Source: Jastreboff AM et al. NEJM 2022 (SURMOUNT-1, n=2,539, 72 weeks). 15 mg tirzepatide produced average −20.9% body weight reduction at 72 weeks vs −3.1% placebo.

Inside the protocol

$349^/mo

Flat retail at every dose. No hidden tiers.

Compounded tirzepatide

The dual GIP/GLP-1 molecule, compounded by a licensed 503A pharmacy partner. Sterile multi-dose vials. Provider-titrated 2.5 → 15 mg. Compounded preparation; not FDA-approved.

U.S.-licensed provider

Your prescription is reviewed and managed by a licensed clinician. Dosing windows and titration coordinated to your response, not a generic protocol.

Direct provider access

Call or text your provider whenever you need to. Dose adjustments, side-effect questions, refills — handled in-thread.

All injection supplies

Sterile syringes, needles, and alcohol prep pads in every shipment. Sharps container included. No add-on charges, no surprise reorders.

Discreet 2-3 day shipping

Insulated, temperature-controlled, plain packaging. Always free, always tracked. Refrigerated stability instructions included.

503A-pharmacy compounded

Prepared by FDA-registered 503A pharmacies under USP <797> sterility standards. Every vial traceable, every batch tested.

Lab panels available as a separate add-on at member rates. HSA/FSA eligible. Cancel anytime.

Start your free assessment →

Transparent pricing. No surprises.

Provider consult, compounded medication, syringes, and unlimited messaging, all included.

LegitScript verifiedLicensed US providersHIPAA-protected503A pharmacy

Compounded tirzepatide

One flat price.
Every dose.

As your provider titrates your dose from 2.5 mg up to 15 mg, your monthly price never changes. No tier upgrades, no dose surcharges, no surprise bills.

Compounded tirzepatide vial
Unlimited messaging with your licensed physician
Sterile syringes & alcohol prep pads
Free 2-3 day discreet shipping
Cancel anytime · HSA/FSA eligible

From

$349 /month— cancel anytime

Same price at every dose — 2.5 mg → 15 mg.

Start your free assessment →

Your physician titrates your dose based on your response. Most patients reach the optimal therapeutic dose by month 4–5.

Your monthly price includes everything.

Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.

Monthly

$349/month— cancel anytime

Billed monthly. Cancel anytime.

Compounded tirzepatide
Provider consultation
Syringes & supplies
Free 2-3 day shipping
Unlimited messaging

Start at $349/mo

Tirzepatide FAQs

Head-to-head trials (SURMOUNT-5) showed tirzepatide produced roughly 50% more weight loss than semaglutide over 72 weeks. Tirzepatide activates both GIP and GLP-1 receptors, while semaglutide only activates GLP-1, which likely explains the stronger effect.

Common (>10%): mild nausea (especially first 1-2 weeks of each new dose), decreased appetite, fatigue, constipation. Most resolve within 2-4 weeks; slower titration helps.

Less common (1-10%): diarrhea or vomiting, headache, dizziness, acid reflux, mild injection-site reaction. Tell your provider — dose adjustments usually fix these.

Rare (<1%): pancreatitis, gallbladder issues, severe allergic reaction, diabetic retinopathy worsening (in patients with diabetes).

Black-box / contraindicated: personal/family history of medullary thyroid carcinoma (MTC), MEN-2 syndrome, pregnancy, breastfeeding, severe gastroparesis.

Call your provider right away for severe stomach pain, signs of allergic reaction, vision changes, or pancreatitis-like pain. Full GLP-1 eligibility & contraindications →

The active pharmaceutical ingredient (tirzepatide) is chemically identical to that used in the FDA-approved branded products. However, compounded preparations are not FDA-approved; the FDA does not verify the safety, effectiveness, or quality of compounded drugs. The compounded preparation is made to your specific prescription by FDA-registered 503A pharmacies under USP <797> sterility standards.

Yes. Many patients switch for stronger results or fewer GI side effects. Your OPTML provider will manage the transition and titration plan.

Not always required, but strongly recommended. We offer an optional comprehensive metabolic panel to establish baseline markers before starting treatment.

Insulated, temperature-controlled, plain packaging. Free 2-3 day discreet shipping. Vials are stable refrigerated; full storage instructions ship with each kit.

Flat $349/mo all-inclusive — medication, provider oversight, syringes, supplies, and shipping. Same price at every dose tier. Cancel anytime.

Compounded tirzepatide,
prescribed online.

Tirzepatide — the dual-pathway molecule, prescribed and delivered.

The most studied molecule in the GLP-1 class.

Tirzepatide vs semaglutide

Tirzepatide

Semaglutide

Everything in your tirzepatide kit

The clinical data behind tirzepatide