What are the side effects?

Most common: nausea, constipation, diarrhea, fatigue, typically mild and temporary. Side effect profile is similar to semaglutide. Your provider starts you at a low dose and titrates up slowly.

How is NAD+ taken — and when?

Daily subcutaneous injection. Most patients take it in the morning to support the day's energy curve.

Can I stack NAD+ with other protocols?

Yes. Many patients switch for stronger results or fewer GI side effects. Your OPTML provider will manage the transition and titration plan.

Do I need labs before starting?

Not always required, but strongly recommended. We offer an optional comprehensive metabolic panel to establish baseline markers before starting treatment.

Cellular energy · Longevity · Mitochondrial support

Restore the cellular fuel your body has lost.

NAD+ is the cofactor that powers nearly every metabolic process in your cells — energy production, DNA repair, mitochondrial health. Levels decline sharply with age. Subcutaneous NAD+ rebuilds the cellular fuel your body has lost. Prescribed by U.S.-licensed providers, shipped to your door.

Cellular energy + mitochondrial support
DNA repair + sirtuin activation
Free 2-3 day discreet shipping
Free provider consult · cancel anytime

Get started How it works →

Includes a consultation with a U.S.-licensed physician

Compounded medication is not FDA-approved. Starting at $179/mo · HSA/FSA eligible.

LegitScript CertifiedHealthcare Merchant

Prescription only Prescribed by U.S.-licensed physicians

Longevity · Cellular energy

Prescribed by U.S.-licensed physicians

Restore the cellular fuel your body has lost.

✓ Licensed US providers✓ 2-3 day discreet shipping✓ Cancel anytime

LegitScript CertifiedHealthcare Merchant

NAD+ is the molecule your mitochondria use to make energy. Levels drop ~50% by age 50, and the consequences cascade: fatigue, slower recovery, dimmer cognition, accelerated cellular aging. Restoring NAD+ restores the substrate your cells need to function.

Cellular energy + clarity
Mitochondrial support
Subcutaneous injection
Cancel anytime

Get started How it works

Starting at $179/mo · Free provider consult · HSA/FSA eligible

The biology of aging

NAD+ powers your cells. Aging makes it harder to keep up.

NAD+ is a coenzyme in nearly every cell, central to energy and DNA repair. Research links aging to lower NAD+ in many tissues. Explore what it does, what affects it, and the pattern researchers see.

your age on the
NAD+ research curve

Tissue NAD+ vs young-adult range

70% (illustrative)

Drag to your age45 yrs

What research links to NAD+

Exercise Sleep Fasting Sun / UV exposure Inflammation Age

General educational information about NAD+ biology and how it is studied in relation to aging. Research on NAD+ and age is evolving and not fully settled: human studies of whole-blood NAD+ have produced mixed results, while direct measurements in tissues such as muscle, brain, and skin more consistently show age-related decline. The curve and percentages are illustrative of a general research pattern, not your levels, not a measurement of any individual, and not a prediction. This makes no claim about any product, medication, or supplement, and does not state or imply that anything offered on this page changes NAD+ levels. What your own status is, and whether anything is appropriate for you, is determined by a licensed physician.

NAD+, explained

The molecule your mitochondria need.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell of your body. It's the molecule your mitochondria use to convert nutrients into ATP — the actual energy currency that powers everything from heartbeat to thought.

NAD+ levels drop ~50% between age 30 and 50. The consequences cascade: fatigue, slower recovery, dimmer cognition, reduced metabolic flexibility, accelerated cellular aging.

Daily subcutaneous injection. Pharmaceutical-grade NAD+ delivered directly under the skin — fastest onset, highest absorption, most reliable serum levels.

The injection is small (insulin-syringe size), virtually painless, and takes seconds to administer at home each morning.

Anyone over 35 who's noticed their baseline energy isn't what it used to be — afternoon crashes, slower recovery, "fog" that wasn't there before. Also patients pursuing longevity protocols who want mitochondrial support alongside other interventions.

NAD+ pairs naturally with TRT, HRT, and sermorelin — addressing the cellular layer that hormones and peptides depend on.

NAD+ is one of the most-studied molecules in longevity research. Documented effects include improved mitochondrial respiration, sirtuin activation, DNA repair, and metabolic flexibility. Clinical NAD+ supplementation has shown improvements in fatigue, sleep, and recovery markers in adult populations.

Sources: Verdin E, Science, 2015. Yoshino J et al, Cell Metabolism, 2018. Martens CR et al, Nature Communications, 2018.

What you get

Everything in your NAD+ kit

No surprises, no upsells. Each shipment includes everything you need to administer safely at home, plus full clinical support.

OPTML NAD+ kit: alcohol prep pad, vial, and pre-paired syringe

NAD+ subcutaneous injection

Pharmaceutical-grade NAD+ delivered as a daily subcutaneous injection. Fastest onset, highest absorption.

Sterile syringes & needles

Pre-paired insulin syringes sized for subcutaneous injection.

Alcohol pads + sharps bin

Everything for safe, sanitary self-administration at home.

Direct provider access

Call or text your U.S.-licensed provider for dose adjustments and questions.

Discreet 2-3 day shipping

Insulated, temperature-controlled, plain packaging. Always free.

What the science actually shows

NAD+ is among the most-studied molecules in longevity science. The numbers below reflect documented effects in human supplementation studies and adult mitochondrial-function literature.

↑ ATP

Mitochondrial respiration + cellular ATP output

↑ Sirt

Sirtuin activation (DNA repair, longevity pathways)

Energy

Sustained baseline energy + reduced fatigue

Sources: Verdin E, Science, 2015. Yoshino J et al, Cell Metabolism, 2018. Martens CR et al, Nature Communications, 2018. Effects vary by individual.

Customer reviewing her OPTML protocol on her phone

How it works

Start NAD+ in 4 simple steps.

Online assessment to first shipment in under a week. No in-person visits, no waiting rooms.

Get started →

Start your online visit

Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.

Provider evaluation

A U.S.-licensed provider reviews your intake and prescribes the right protocol, if appropriate.

Personalized plan

Compounded NAD+, syringes, and supplies arrive in 2–3 days. Protocol tailored to your goals.

Ongoing support

Message your provider anytime. Dose adjustments, refills, and questions handled in-app.

9:41

Question 1 of 12

What do you want to accomplish with OPTML?

Lose weight
Energy & vitality
Cellular energy & longevity
Optimize hormones

Start NAD+ in 4 simple steps

Start your online visit

Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.
Provider evaluation
Personalized plan
Ongoing support

Get started →

No commitment. No insurance needed. See full eligibility & contraindications →

Transparent pricing. No surprises.

NAD+, provider oversight via call or text, all supplies, and free shipping included.

Physician-directed care

A U.S.-licensed physician personally reviews every order before anything is prescribed.

U.S.-licensed physicians
Reviews every order
LegitScript Certified
503A pharmacy · USP <797>

Compounded NAD+

One flat price.
Every dose.

Subcutaneous NAD+ prescribed and titrated to your response. Your monthly price stays the same regardless of dose tier.

Compounded NAD+ vial
Ongoing clinical support
Sterile syringes & alcohol prep pads
Free 2-3 day discreet shipping
Cancel anytime · HSA/FSA eligible

From

$179 /month— cancel anytime

Or $489 every 3 months — flat retail at every dose.

Get started →

Daily subcutaneous, dosed to your response. Patients typically take it in the morning to support the day’s energy curve.

Your monthly price includes everything.

Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.

Monthly

$179/month— cancel anytime

Billed monthly. Cancel anytime.

NAD+ subcutaneous injection
Provider oversight via call or text
All supplies (syringes, alcohol pads)
Free 2-3 day shipping

Start at $179/mo

Best Value · Save $48

3-month supply

$489/3 months

One shipment, billed quarterly. Cancel anytime.

NAD+ subcutaneous injection
Provider oversight via call or text
All supplies (syringes, alcohol pads)
Free 2-3 day shipping

Start at $489 / 3 mo

NAD+ FAQs

Not exactly. NMN and NR are NAD+ precursors — your body has to convert them. NAD+ subcutaneous injection delivers the molecule directly. Faster onset, higher serum levels, more reliable absorption — at the cost of a prescription requirement and clinical oversight.

Daily subcutaneous injection, taken in the morning to support the day's energy curve. The injection is small (insulin-syringe size) and takes seconds. Split dosing also works for some patients.

Energy and mental clarity often shift within the first 7-14 days. Sleep depth and recovery improvements show in weeks 3-6. Sustained baseline lift compounds over 8-12 weeks as cellular NAD+ pools rebuild.

Common: mild injection-site reactions (transient redness), occasional warm flushing or vivid dreams in first nights. Less common: mild headache or fluid retention. Most resolve within the first 2-4 weeks.

Contraindicated in active malignancy, pregnancy, breastfeeding, or with severe untreated diabetic retinopathy. Full eligibility & contraindications →

Not always required, but a baseline metabolic panel is recommended for patients pursuing comprehensive longevity protocols. The OPTML lab panel is offered as a separate add-on at member rates.

Yes — NAD+ is the most stackable molecule on the menu. It pairs naturally with TRT, HRT, and sermorelin because it supplies the cellular substrate hormones and peptides depend on. Many longevity-minded patients run NAD+ as a continuous baseline protocol.

Insulated, temperature-controlled, plain packaging. Free 2-3 day discreet shipping. Vials are stable refrigerated; full storage and reconstitution instructions ship with each kit.

Flat $179/mo for the monthly plan, or $489 every 3 months for the 3-month supply (saves $48 over 3 months). Includes the medication, provider oversight via call or text, all supplies (syringes, needles, alcohol pads), and shipping. Lab panels are a separate add-on at member rates. Cancel anytime.

Restore the cellular fuel your body has lost.

Restore the cellular fuel your body has lost.

NAD+ powers your cells. Aging makes it harder to keep up.

The molecule your mitochondria need.

NAD+ pairs with every protocol.

Everything in your NAD+ kit

What the science actually shows