E2 sensitive
The most important estrogen — measured by a sensitive assay accurate for both men and women.
What is it
Estradiol is the primary estrogen in reproductive-age women and is also important in men. The 'sensitive' assay uses mass spectrometry to accurately measure the lower values typically seen in men and postmenopausal women.
Why it's measured
Estradiol has been associated with bone health, cardiovascular health, cognition, and mood in published research across both sexes.
Reference range
Standard laboratory reference
Men: 10 – 40 / Women (cycle-dependent): 30 – 400 pg/mL
Reference ranges vary by laboratory. Your individual reference range will appear on your test report and should be interpreted by your physician in the context of your overall health profile.
What results may indicate
Elevated
In men or postmenopausal women, may warrant evaluation. In premenopausal women, must be interpreted in context of cycle day.
Lower
Has been associated with bone density loss, mood changes, and cognitive changes in research literature.
These associations are general. They are not a personal diagnosis or prediction. Discuss your individual results with your physician in the context of your full health profile.
When it's measured
Often measured alongside testosterone in men and during reproductive hormone evaluation in women.
Related markers
Common questions
Estradiol is the primary estrogen in reproductive-age women and is also important in men. The 'sensitive' assay uses mass spectrometry to accurately measure the lower values typically seen in men and postmenopausal women.
It's one of the markers used to build a fuller picture of your health. On its own it tells you very little, so it's most informative when reviewed alongside related markers.
It's measured from a standard blood draw at Quest or LabCorp. Estradiol (sensitive) is one of the markers included in the OPTML Apex Panel, where your results are read across systems and reviewed by a U.S.-licensed physician.
Reference ranges vary by laboratory, and a single value rarely tells the whole story. Review your result with a physician in the context of your other markers, symptoms, and history.
Estradiol (sensitive) is one signal among many. Answer a few quick questions and we’ll point you to the panel that fits.
Measured in
A complete look at your heart, hormones, metabolism, inflammation, and longevity systems — drawn at Quest or LabCorp, reviewed by a U.S.-licensed physician.
Explore the Apex Panel →This information is for general educational purposes only and is not medical advice. Lab results alone are not intended to diagnose, treat, or cure any condition and do not replace the advice of a healthcare provider. OPTML does not offer medical advice, a diagnosis, medical treatment, or any form of medical opinion.